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Diabetes Mellitus-Vitamin E

C.Vitamin E:
Vitamin E reduces oxidative stress, thus improving membrane physical characteristics and related activities in glucose transport.This antioxidant promotes healing of diabetes-related lesions, whose cause is undetermined. Researchers have extensively investigated the possible effects of vitamin E supplementation on the cardiac autonomic nervous system in patients with type 2 diabetes and cardiac autonomic neuropathy. It was reported in the American Journal of Clinical Nutrition that daily vitamin E supplementation (600 mg) for 4 months improved the ratio of cardiac sympathetic to parasympathetic tone in patients with NIIDM.

This effect might be mediated by a decline in oxidative stress. In short, Vitamin E (800 to 1200 I.U.) improves insulin action and prevents a host of long-term complications of diabetes including neuropathy.In another study, 21 NIIDM patients with microangiopathic complications were divided into 2 groups, in which 11 patients took 900 mg of vitamin E daily and the other group of 10 diabetic patients took a placebo daily for 6 months. The vitamin E was provided in tablets containing 100 mg of dl-alpha-tocopheryl acetate.The mean age of these subjects was 58 years. This study showed that these diabetic patients had impaired erythrocyte osmotic fragility, and that pharmacological doses of vitamin E increased the resistance of erythrocytes to osmotic hemolysis in patients with microangiopathy.Vitamin E also appears to play a significant role in the prevention of diabetes. Studies have shown that a low vitamin-E concentration was associated with a 3.9 times greater risk of developing diabetes.

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