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Millions of Britons given Indian-made AstraZeneca doses ‘could be excluded from EU vaccine passport scheme’

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Millions of Britons given Indian-made AstraZeneca doses ‘could be excluded from EU vaccine passport scheme’

Millions of Britons could be shut out of European holidays because some AstraZeneca jabs are not automatically recognised by the EU vaccine passport scheme, it was reported on Friday.

The new EU Covid certificate, designed to open up travel for those immunised against the virus, does not include batches of the vaccine produced in India because they have not been approved by the European Medicines Agency (EMA).

The UK is among many countries to have approved the so-called Covishield version of the AZ jab, made by the Serum Institute of India. It is chemically identical to the original AZ version.

a hand holding a bottle: A man in Ghana shows a vial of the Indian-made Covishield version of the AstraZeneca vaccine, which has also been used in the UK - Reuters

Up to 5 million Indian-made doses have been administered in the UK, the Daily Telegraph reported, identifiable by their batch numbers as shown on patients’ card or in the NHS app.

Those Britons could be turned away at EU border crossings, the newspaper said.

Many other countries – including India itself – are also affected because the Indian-made version accounts for the majority of AZ doses supplied to poorer nations as part of the Covax vaccine-sharing scheme. 

However, EU member states may accept non-EMA-approved vaccines if they wish.

Germany and Spain are among nine EU members who have told India they will accept the Covishield version, Indian foreign ministry sources told Associated Press.

The EMA said on Thursday it has not received any application for authorisation of Covishield, the version of AstraZeneca’s vaccine made by the Serum Institute of India 

Reference: Independent: Alastair Jamieson

80% of hospitalized COVID patients develop a neurological condition

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80% of hospitalized COVID patients develop a neurological condition

A majority of hospitalized COVID-19 patients develop neurological problems, a new study suggests.

Researchers from the University of Pittsburgh surveyed thousands of former COVID-19 patients from around the world on symptoms they were experiencing post-hospitalization.

They found that 80 percent developed conditions such as being in a coma, suffering a stroke or even damage to the brain.

What's more, this group of hospitalized patients were six times more likely to die because than hospitalized patients without neurological problems.

For the study, published in JAMA Network Open, the team surveyed 3,744 people COVID-19 patients aged 18 and older.

The participants self reported any potential issues they were facing that could be side-effects of a neurological condition. 

Eight in 10 patients had at least one of the conditions or reported some sort of side-effects - with some being found to have multiple. 

A total of 37 percent reported frequent headaches and 26 percent reported either a loss of taste or smell. 

Nearly half, 49 percent, of participants were found to have acute encephalopathy, a condition that alters someone's brain structure.

a man standing in front of a store: MailOnline logo

Going into a coma, 17 percent, or experiencing a stroke (6 percent) were common conditions as well.

'We expected there'd be some, but that was a lot,' said Dt Sherry Chou, lead author of the study, professor at the University of Pittsburg, said in a press release.

'These are people who are confused, who are delirious, who are not themselves.' 

'They have altered sensorium, memory problems, and about every other person hospitalized with COVID-19 had that condition.' 

Researchers are still unsure how COVID-19 manifests in this way, and why it can cause so many conditions in so many parts of the body.

Separate from neurological issues, some people develop myocarditis, heart inflammation, after having the virus.

Others even end up bed-ridden for as long as a year with a condition called 'long-haul COVID', where they experience incredible fatigue and other symptoms of the virus long term.   

More than 33.6 million Americans have contracted the virus since the pandemic began in spring 2020. 

While a vast majority have recovered, finding out what the virus did to the bodies of the people it infected will be a challenge for the scientific community in the years to come.   

Chou says that, in the future, she hopes to conduct research that answer how long neurological symptoms last in COVID-19 patients and what are the long-term effects.

'And the key question is: "How do we treat it?'" she said. 

Reference: Daily Mail: Mansur Shaheen For Dailymail.Com

Trapped nerves giving you grief? Here’s what a leading pain expert advises

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Trapped nerves giving you grief? Here’s what a leading pain expert advises

Whether it’s sharp and sudden or dull and constant, pain from a trapped nerve is hard to ignore.

While pinched nerves aren’t uncommon, they can cause a major amount of discomfort, leading to sleepless nights and misery while performing even the simplest of everyday activities.

Often, the first step in getting relief from any kind of pain is identifying the source, and making sure a trapped nerve really is to blame. So if your symptoms are severe or ongoing, it’s a good idea to get them checked by a doctor or physio.

To find out more, we spoke to leading UK pain expert Dr Anthony Ordman (dranthonyordman.co.uk), who founded the Royal Free Hospital’s pain management clinic in London.

What are trapped nerves and why do they happen?

Pinched or trapped nerves are thought to occur when pressure is put on an area of a nerve, causing it to send warning signals to the brain. Ordman says they can appear in many different areas of the body, as the compression is caused by surrounding tissues, such as bones, cartilage or tendons.

“The most common examples include the neck, where the pain goes over the shoulder, down the arm and sometimes into the hand, or from the lumbar spine where the pain travels the leg – which is is what we commonly refer to as sciatica,” says Ordman.

“Other examples include pudendal nerve pain in the pelvis, which happens when the nerve is pinched by two ligaments or squashed by a bike saddle, causing intense pain in the groin.”

a man looking at the camera: Man with pinched nerve -

What are the symptoms of a trapped nerve?

Sometimes, pain might be your only symptom, although you could experience other warning signs too.

As Ordman notes: “The nerve pain itself can feel like a sensation of intense pressure or burning, and it may feel like tiny electric shocks or tingling. At the same time, you can also experience numbness in the region of the nerve, which is a strange and contradictory sensation all at once.”

The discomfort happens, Ordman says, because the nerve is being squashed, so it sends the brain a message, which it interprets as pain. There may also be a feeling of muscle weakness in the affected area.

How is nerve pain treated?

If you’re suffering with a trapped nerve, rest assured that most cases go away on their own, and often quite quickly in a couple of days. “In the case of neck and lumbar spine pain, changing your posture and visiting a good physiotherapist may be enough,” says Ordman.

Alternating between applying a heat and ice pack can help you to find relief – but make sure to wrap them in a towel before applying directly to your skin. Massage therapy, through the use of a handheld massage tool, can help to stimulate circulation in the affected area and bring soothing benefits.

“Sometimes anti-inflammatory drugs such as ibuprofen can help, but they shouldn’t be taken long term. Painkillers such as paracetamol are not particularly helpful with nerve pain,” Ordman adds.  

 a close up of a man: Woman with nerve pain

 “There are specific medicines to treat nerve pain, including gabapentin, amitriptyline and pregabalin, but these drugs will only help one person in around four, and they usually have side-effects, such as sedation and memory issues or brain fog.”

You will need to speak to your doctor about these types of medicines, to ensure they are suitable and side-effects are monitored. Ordman adds that pregabalin can be very addictive too, so should be prescribed in a controlled way.

“Newly available medicines, such as medical cannabis, are being increasingly turned to, and they can be very useful in treating the symptoms of nerve pain,” says Ordman.

Treatment will often depend on the severity of symptoms and their underlying cause, and more extreme measures – like surgery – are usually a last resort, when more conservative measures have not worked. “Sometimes surgery is needed to save a slipped disk, or doctors can inject steroids around the pinched nerve, but such treatments are not available to everyone,” says Ordman. 

Is it ever serious or something to be concerned about?

Ordman says trapped nerve pain generally isn’t serious, but it can be. “Nerve pain can be very distressing and it can also restrict freedom of movement and sleep too. Occasionally it can be very serious, where the nerve supply to the bladder or legs might become compressed, which could lead to problems emptying the bladder, or disfunction and weakness of the legs. In this situation, urgent surgery would be required,” he explains.

Are there any measures we can take to prevent it?

As with most health issues, self-care and living a healthy lifestyle is often key to prevention. Ordman says maintaining a good posture (such as avoiding crossing your legs for too long), incorporating strength and flexibility movements into your routine, and taking breaks from repetitive activities can all help to keep your nerves pain-free in the long run.

However, you should speak to a doctor if your pinched nerve symptoms last for several days and haven’t responded to rest and painkillers.

Reference: Independent: Liz Connor 

Mother, 47, dies after AstraZeneca Covid jab caused blood clots

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Mother, 47, dies after AstraZeneca Covid jab caused blood clots

A mother-of-three has died after suffering a rare catastrophic reaction to the AstraZeneca coronavirus jab, her family has said.

Lucy Taberer, 47, fell seriously ill after getting the jab and developed blood clots in her brain which caused a stroke.

Her heartbroken fiance, Mark Tomlin, from Aylestone in Leicester, has since spoken about the devastating impact her death has had on the family including the couple's five-year-old son Orson.

He said Lucy, a playgroup leader who had no known health conditions, initially experienced mild side effects in the days after she was vaccinated at the Peepul Centre in Belgrave on March 19.

But her condition gradually worsened, causing her to be rushed into hospital. Despite best efforts by medics to save her, she died 22 days after being vaccinated.

A post-mortem found the mother had suffered from cerebral venous sinus thrombosis - a rare and deadly type of brain clot.   

Mr Tomlin said: 'I don't want people to be put off having a vaccine but I do want people to know that there are risks.

'We're not anti-vax. Lucy certainly wasn't - she was so excited about getting it.'

What is the risk of getting blood clot after AstraZeneca's jab? 

In total 389 Britons have suffered blood clotting disorders after receiving the AstraZeneca vaccine, of which 68 died. The NHS has deployed 45million doses of the British-made jab.  

Under-40s are being given alternatives to AstraZeneca's vaccine because the conditions seem to be affecting younger people more often. 

Speaking about Lucy's experience, Mr Tomlin said: 'She knew there might be some side effects but she wasn't worried. We thought they would just clear up as most people's do.

'That reassured her and she didn't think it was anything to do with the vaccine but things just started to get worse and the panic began.

'She developed a bruise about the size of a tennis ball on her.  Normally she had all the energy in the world but she became tired and lethargic.

'Then she got a really bad rash on her face and side. Her gums started to change colour and we got really worried.'

On April 1 - 13 days after her vaccination - Lucy was rushed to the Leicester Royal Infirmary where blood clots were diagnosed.

What is the risk of getting blood clot after AstraZeneca's jab? 

British health chiefs last month recommended all under-40s are offered an alternative to AstraZeneca's vaccine because of blood clot fears.

A total of 389 cases of a rare clotting disorder have been spotted among 24.5million recipients of the jab — or around one in every 75,000 people. Sixty-eight patients have died.

But statisticians analysed the numbers and found rates were slightly higher among younger adults, with females appearing to be at most risk, too.

Cambridge academics estimated around 1.9 in every 100,000 twenty-somethings given AstraZeneca's jab would suffer serious blood clots alongside abnormally low platelet levels (thrombocytopenia) — the specific disorder linked to the jab. For thirty-somethings the figure was 1.5.

They compared that against the average number of Covid intensive care admissions that would be prevented by giving that cohort the jab. And they then analysed the risk/benefit ratio in different scenarios, based entirely on how widespread the disease was at the time.

For example, only 0.2 ICU admissions would be prevented for every 100,000 twenty-somethings given the jab at prevalence levels seen in April (fewer than 30,000 infections per week). For adults in their thirties, the figure was around 0.8.

It showed, however, the benefits of giving AstraZeneca's vaccine to 40-49 year olds outweighed the potential risk (1.7 prevented ICU admissions per 100,000 people compared to 1.2 blood clots).

But the decision to recommend under-40s are offered Pfizer or Moderna's jab instead was basically only taken because the outbreak was squashed to extremely low levels, as well as the fact younger people are known to face tiny odds of falling seriously ill with coronavirus.

For older adults, who the disease poses a much greater threat to, the benefits of vaccination are clear, regulators insist. Jabs have already saved around 13,000 lives in England, top scientists believe.

However, because there were so few blood clots, it made it impossible for No10's vaccine advisory panel to give an exact age cut-off. Instead, they were only able to analyse figures by decade.

The first clots to alarm people were ones appearing in veins near the brains of younger adults in a condition called CSVT (cerebral sinus venous thrombosis).

Since that, however, people have developed clots in other parts of their bodies and they are usually linked to low numbers of platelets, which is unusual because platelets are usually used by the immune system to build the clots.

In most cases people recover fully and the blockages are generally easy to treat if spotted early, but they can trigger strokes or heart or lung problems if unnoticed.

Symptoms depend entirely on where the clot is, with brain blockages causing excruitiating headaches. Clots in major arteries in the abdomen can cause persistent stomach pain, and ones in the leg can cause swelling of the limbs. 

Researchers in Germany believe the problem lies in the adenovirus vector — a common cold virus used so both vaccines can enter the body.

Academics investigating the issue say the complication is 'completely absent' in mRNA vaccines like Pfizer's and Moderna's because they have a different delivery mechanism.

Experts at Goethe-University of Frankfurt and Ulm University, in Helmholtz, say the AstraZeneca vaccine enters the nucleus of the cell – a blob of DNA in the middle. For comparison, the Pfizer jab enters the fluid around it that acts as a protein factory. Bits of coronavirus proteins that get inside the nucleus can break up and the unusual fragments then get expelled out into the bloodstream, where they can trigger clotting in a tiny number of people, scientists claim.

Doctors treated her with blood thinning drugs but her condition worsened still but she had blood clots and she suffered a massive stroke.

She was then transferred to the intensive care unit at Nottingham's Queen's Medical Centre (QMC) but, despite surgery to save her, consultants said there was nothing more that could be done for her and recommended her life support be switched off on April 10. 

Mark, a 57-year-old metal worker, said it was consultants at the QMC who said Lucy's severe illness was vaccine-related. Her death certificate says she died of cerebral venous sinus thrombosis and vaccine-associated thrombosis with thrombocytopenia. Mark said: 'We were so happy and looking forward to the future and then suddenly I'm having to explain to Orson that his mummy has died. 'I'd already told him that mummy had gone into hospital because she needed medicine.

'Then I told him that the medicine hadn't worked, and that mummy couldn't come home then a couple of days later I told him that she had died.

'Our world has been turned upside down. Every day I wake up and Lucy is the first thing I think about.'

Mark said: 'I don't want people to be put off having a vaccine but I do want people to know that there are risks.

'We're not anti-vax. Lucy certainly wasn't - she was so excited about getting it.

'She's stuck like glue to all the lockdown rules and saw the vaccine as a step to getting out again and seeing her and hugging her mates.

'She couldn't wait to get it but nobody thought this would happen.'

Mark said that Lucy had had expressed some concerns about the process on the day she was jabbed - centring on how quick her vaccination had been carried out and that it had not been explained well to her.

He said he would have been happier if she had got her jab a GP surgery as he did.

He said: 'I had my first dose (of Pfizer) at my GPs where they were really good in talking through the process.

'I still don't think I'll get my second dose after everything that has happened.

'I'm not saying people shouldn't get vaccinated. It's every individual's choice.

'I do know how rare it is for things to go so badly wrong but it has happened to us and that has affected how I think about things myself.'

A spokesperson for the Leicester City NHS Clinical Commissioning Group, which is running the vaccination programme in the city, told LeicestershireLive: 'We were very sorry to hear of Lucy's death, which is clearly very tragic and deeply upsetting for Lucy's family and friends.

'All vaccination sites - temporary such as pop - ups or fixed - are subject to strict operating procedures covering all aspects of the service.

'This includes vaccine storage and handling, infection protection and control, workforce requirements and training, and have clinical supervision. 

'The safety of patients is paramount and the operating process includes arrangements for consent, observation and responding to incidents.'

Mark's daughter Leanne, 33, is now helping him care for Orson.

She stressed the family did not want to put others off having the vaccine.

'That's not what this is about at all but we think it is important that people know what happened to Lucy and that cases like hers are not forgotten', she said.

Leanne said Lucy's case had been reported to the Government's Yellow Card service where adverse reactions to vaccines can be recorded.

More than 200,000 cases of such reactions to the AstraZeneca vaccination had been recorded by Yellow Card by June 9.

The Joint Committee on Vaccination and Immunisation has recommended healthy people under 40 years old be offered an alternative to the AstraZeneca vaccine.

Other countries have suspended its use over concerns it can cause clots.

The Department of Health and Social Care said: 'Extremely rare cases of blood clots with low levels of platelets have been observed following vaccination with COVID-19 Vaccine AstraZeneca.

'The majority of these cases occurred within the first 14 days following vaccination but some have also been reported after this period. Some cases were life-threatening or had a fatal outcome.

'It is important to remember the benefits of vaccination to give protection against COVID-19 still outweigh any potential risks.'

Mark has had to cut the hours he works by half since Lucy's death to look after Orson and that has led to him struggling financially.

Leanne set up an online fundraising page to help with childcare and other costs and support Orson which has raised more than £9,000.

She said: 'We have been blown away by the reaction and people's generosity.' 

The BBC star, model and mother-of-three who have died after receiving the AstraZeneca Covid vaccine 

Tanya Smith 

Childminder Tanya Smith, 43, had her first AstraZeneca jab in March and died just over a week later after being rushed to hospital with severe stomach cramps.

An inquest is set to take place to determine the circumstances surrounding the mother-of-three's death.

The Medicines and Healthcare products Regulatory Agency later confirmed it will review Ms Smith's case as part of an ongoing review into the occurrence of blood clots and any potential links to the vaccine.

Ms Smith's partner Kenneth Edwards said Tanya had felt 'pretty rough' for a couple of days after the jab and then woke one morning in pain and called 111 for help.

He said her suffering did not ease even after a paramedic attended and gave her painkillers and she was taken to Derriford Hospital where it was later found she had suffered multiple blood clots.

Lisa Shaw  

Lisa Shaw, who worked for BBC Newcastle, developed 'severe' headaches a week after having the jab and fell seriously ill a few days later, relatives said in a statement.

Ms Shaw, 44, died at the Royal Victoria Infirmary, Newcastle, on May 21 having been treated in intensive care for blood clots and bleeding.

A fact-of-death certificate lists the vaccine as one of the possible factors but document does not determine a cause of death.

It is expected that will only be released following an inquest into her death. 

The presenter was not known to have any underlying health problems and her death came as a devastating shock to family and colleagues. 

Stephanie Dubois  

British model Stephanie Dubois died in a Cypriot hospital last month after a blood clotting incident after receiving the AstraZeneca Covid-19 vaccine. 

The 39-year-old suffered a brain haemorrhage and was in a coma before her death.

Cypriot health authorities are currently investigating whether Dubois's death was linked to the AstraZeneca jab.

The model posted publicly about feeling ill after having the vaccine on May 6.

Ms Dubois had said that she felt 'horrendous' after the first dose and fell ill days later.  

Neil Astles  

Neil Astles, 59, from Warrington, became the UK's first named victim of blood clots after receiving the AZ vaccine when he passed away on Easter Sunday.

Mr Astles suffered 10 days of severe headaches and a steady loss of vision.

His sister Dr Alison Astles, a pharmacist at the University of Huddersfield, said her brother was a keen runner, was 'fit and healthy' and had no history of blood clots.

But he developed a headache about a week after his vaccination March 17. 

When his headaches and eyesight worsened, he was rushed to A&E at the Royal Liverpool Hospital by his brother, before being admitted to intensive care, where he died more than a fortnight later.  

Reference: Daily Mail:Raven Saunt For Mailonline

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